Not sure what are you talking about. The best moment to speak about anything is ASAP. I am not going to wait until next 1-on-1 meeting day because that's the procedure. I am not going to track the bullets of interesting topic throughout a week and wait either because I have many better ways to spend my time at office, like contributing to the project. If I have anything that needs a discussion I go to manager and talk, or I go out for a lunch with him. It works both ways. A 1-on-1, to me, is an artificial construct created so the organization can mark a goal completed "we are trying to foster a better culture and growth environment, blah blah blah." What are you talking about when there is nothing to talk about? Not because of hostility - just everything has been already discussed. Don't get me wrong here. I am on very good terms with my manager and we have not always easy but honest communication channel for few years, now. We just cancelled our 1-on-1 and I couldn't be more happy about it. None of us lost anything.