No matter what disease you are worried about, it seems like you need to follow the same advice in your day to day life: eat better, smoke less, drink less, exercise more, sleep appropriately.
Most of my favorite forms of exercise (climbing, hiking, running) are pretty hard on my joints, along with several other risks like shin splints and pulley injuries. I know there's some capacity to strengthen tendons and ligaments, but I can't find decent data on what tradeoffs I'm making at what levels of activity. Replacing everything I do with swimming and intermediate-rep weight training would almost certainly offer a better tradeoff, but I want to at least work out what price I'm paying.
More important in many ways is knowing what pain is a sign to immediately stop, and take time off to recover from. Taking a week or two off now can prevent significant long term issues.