Ex-Amazonian here.

Aside: Despite the company's not-so-good reputation in the media and forums, I enjoyed working there. For the most part I had good managers and coworkers. And once you've been there a while, you can transfer to a team with more interesting work, less on-call support, etc.

Anyway, my wife is a doctor, and she had to move for her residency. Amazon wasn't willing to consider remote work, and I'm not sure I'd want to be the one "remote guy" anyway, so I switched jobs to a 100% remote company. We're hiring, in case others would like to make a similar jump. :)