Do we really live longer than our ancestors?
bbc.com
bbc.com
The benefits of some of those advances are questionable at best. Those who have visited a nursing home may know what I'm talking about.
Spending the last decade of your life commuting to doctor's offices (or bedridden) ain't no picnic, nor is rotting away in a forgotten corner of a human warehouse.
The quality of life position has always intrigued me for this reason. Sometimes what technology giveth with one hand, society taketh away with the other.
It's kind of anecdata, but have you ever noticed how in classical books from a few hundred years ago, it's sort of normal that Mr So & So might be on his third or fourth wife because the others died in childbirth? Just something that caught my attention.
My wife's aunt passed away last year from some kind of brain issue (I never did figure out exactly what the problem was -- lack of vocabulary). She was in and out of the hospital for about 3 months and while distressing, I think she very much appreciated being alive in those 3 months. After that she essentially ended up in a kind of semi-coma where she was awake for maybe an hour a day -- and she was in a nursing home. After another 5 months or so she passed away. I don't know if she got much value from those 5 months, but I know her husband definitely was able to use the time to come to grips with the reality of the situation. Again, just an anecdote, but I think it's illustrative of the complexity of the situation.
Anyway, I think most people can look forward to enjoying their old age. Of course it makes a big difference if you look after your body when you are young and it is much easier to do so.
>On the other hand, because I live in rural Japan and am only really friends with the people who live near me, almost all of my friends are over 70 (I'm 50).
I'm in a pretty similar situation ... guess from your profile that it's OK to hook up with you by email ?
That's not what selection bias is -- that's just an accurate reporting of what you see around you. It would be selection bias if you additionally claimed that this must be the case elsewhere too.
Perfect disclaimer on the limitations of his analysis because of the selection bias inherent in the data sample.
That said, euthanasia would be a great option to have for those with chronic ailments.
The leading cause of death in the US in 1980 was heart disease. It is still the leading cause of death today. However, the absolute number of deaths due to heart disease has declined by 17% from 1980 to 2015. This is despite the population growing by 42%. That is pretty amazing.
I don't have data on exactly what contributed to this decline in heart disease deaths, but I'd bet it is better drugs. The first statin was approved in 1987. ACE / ARB inhibitors were approved in the 1980s and 1990s. Again I don't have data on exactly what caused the decrease in cardiovascular disease deaths but would love to hear if others do. Nutrition and lifestyle (less smoking?) could have played a role as well, but diabetes deaths have increased a lot, so I don't think lifestyles have become too much healthier
The second leading cause of death is cancer. The number of deaths from cancer has roughly tracked population growth.
The third leading cause of death in 1980, stroke, has seen absolute numbers of deaths drop by 18% from 1980 to 2015
Is this a good metric though? It seems to me that (1) once you get cancer, you always have cancer, and (2) if nothing else kills you, cancer does. So maybe a better metric would be, the lifespan of people with cancer?
Unfortunately I don't have data either, but I do have a hypothesis that may or may not end up surviving scrutiny when the relevant data becomes available. If someone can refute these ideas, please contribute.
The ultimate cause: demographics changed.
The recent decades have seen native populations reduce their fertility in the US. This is analogous to ecological succession of pioneering species colonizing barren land building up new soils by quickly flourishing and in turn crowded out in competition as other species take hold in niches opened by the pioneers laying a rich framework however being unsuccessful at sustaining dominance due to the energetic and fitness costs of extreme adaptation in resource poor environments that are unable to be useful traits relative to other species that can quickly capitalize on existing infrastructure when there's no need to divert capacity to build anew when resources become abundant. Today when applied to populations of humans in the US, the same principal goes under names like "white flight" as fleeing urbanization to recreate past conditions that were more favorable in competition strategies, "gentrification" when enclaves of urban areas decay and are then susceptible to recolonization efforts, and "immigration" to relieve bottlenecks in reproduction and the resulting scar of exposed barren land and poor nutrient circulation in the ecosystem that are caused by pioneer individuals stockpiling reserves without reinvesting in reseeding efforts.
Heart disease is typically a progressive terminal stage of diabetes and other metabolic disorders that intertwine risk factors such as poor nutrition, excessive calorie consumption and resulting unhealthy body fat percentages, alcohol abuse, cigarette use, and high stress. Looking closure at the medical literature, I'd actually reconsider the idea that statins produce beneficial health outcomes, but I won't get into that in this comment.
The point here is that in heart disease being the cumulative effects over a lifetime and diabetes as a _leading_ (not trailing) indicator of population risk for heart disease, what you're really seeing is the transition of health since WW2 when war rationing forced the agricultural and food processing industries to change course in providing massive amount of calories at low cost and effective propaganda and marketing to ensure sustained demand when the war was over to not shock the economy back into depression. Heavily processed foods like spam, American cheese, and canned/dried foods are technological means to make food supplies go further with less waste and higher caloric density. Add in things like pushing cigarette consumption heavily after the war and you get the perfect storm that kills off a large percentage of the lower class baby boomer generation early in life by around the 1980s. What's left since then are the middle and upper class baby boomers whose children reproduce in far lower numbers, being replaced with immigrants. Those immigrants come here with very different cultures regarding food consumption, nutrition, and healthcare that for a period of time did decrease the incidence of influence of the cultural epidemic of war-era food technology.
Usually after one generation though, immigrant families transition to the already establish cultural expectations and shift dietary and consumption patterns. Therefore you get the next surge of diabetes as the form of the next incarnation of the cycle. In a few decades you'll see another recurrance in more prevelent heart disease.
Which ones?
Some people might still think these are good things. I think "questionable at best" is a good summary.
So naturally the state of those placed in a nursing home is dire, and when you view the nursing home as a place for the old rather than for what it is it’ll give you the idea that old age isn’t something to strive for.
In reality, however, a nursing home is really a long term hospice and everyone who live there is slowly dying from a range of diseases. Often because they didn’t live healthy lives.
That’s not what old age has to look like though. More and more people are living rich lives even after they turn 90, and while we can talk about the quality of life of those who don’t, the technological advances are also helping people who don’t go to nursing homes.
It’s sepecially helping with mobility, so that people who get sick in a non-lethal way, like getting pains from walking, can stay out of the nursing home longer than they used to.
On the surface, we like to say how we're providing care and have their best interests in mind as they "age well" and as we repay the debt of elders who took care of us so dutifully for years.
But in reality, the main usage is to get rid of very burdensome, cantankerous, and irresponsible leeches who because they left their children with a sense of hatred will not give in to the idea of putting up with their crap ever again, so let them rot all drugged up in a coma where they cannot escape as they watch TV in a urine-soaked room and play bingo every Wednesday night until they die off.
It's more a short-term fix for us though, a pretty typical American form of cutting off the nose to spite the face since national spending is sprialing out of control from dealing with the old and will become a larger economic problem. Ironically, it does force the hand of the young in later years once filial laws come back in full swing enforcement who will end up saying enough is enough and euthanasia legalization legislation will come swooping in to deal with this.
These feelings are universally shared, but only visible to most in times of scarcity and fear. When economies are bubbling along in mania, people tend to lose sight of the eventualities regarding unsustainable societies. It's easy for people to rationalize their actions as charity, benevolence, and empathetic concern when they themselves are rewarded daily for vocalizing the whitewash and justifying what should be by what is now. When the music stops and individuals are left to fend for a chance at a seat, the full intention of previous actions becomes apparent as if malice is not something definable by planned greed and desire but puppetered unknowingly by a more clairvoyant self that protects its fragile present with the blessing of moral amnesia.
I do know for sure nursing homes are definitely used to "remove a burden." Dealing with elders at that stage of life can very taxing, and many people would rather simply avoid it. They may even, as the poster hinted at, dislike their family member. However, even then I don't think they share as strong emotions as the poster.
Whatever the case, I'd welcome research into attitudes towards eldercare. Right now, I feel like we're flying blind. For instance, I wouldn't be surprised whatsoever if GenX'ers (like me) would rather die than be warehoused. But no one I know is thinking that far ahead, having these discussions with their kids. Nor are our parents discussing this with us, now that it's our turn to be the care givers.
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For instance:
Family Involvement in Residential Long-Term Care: A Synthesis and Critical Review [2008]
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247412/
"... These collective findings have helped debunk the myth that families abandon their relatives in nursing homes or similar settings to die in isolation..."
If you happen to wonder "what went wrong with this guy that caused him to become so jaded?" and contend that "he doesn't speak for all of us, I'm different!" well I will say it is very true that I am sort of an anomaly in current sentiment. Most people do not like how I end up deconstructing the world I perceive and view my analyses as ususally extremist, having getting kicked out (or desperate attempts at 'rehabilitative' disciplinary action) of nearly every organization I've ever been a part of from gatherings of family and friends to Sunday schools and churches, scouting, schools, and companies alike. I realize due to the repeating pattern the problem is most likely seated in myself, but if you're listening you still may like to entertain the idea that the superficial gloss we paint the world in vain attempting to heal our souls could in fact only be concealing a necrotic core. Maybe not out of actual belief in such a situation, but only to check due diligence off the list and set your mind at ease that judgement of our times will be favorably looked upon and your decisions were made with principled reason rather than excuses of being led astray by deception.
Sure.
I reprogrammed myself. I chose to be positive, optimistic. It took years.
Life is a gift, every day a celebration. I rejected the recurring debilitating existential terror. I now find joy wherever I can, however I can, and do good works as able.
Good luck.
(Another alternative of course popular in some cultures is to let them toil away even at 70 or more, and have them live alone and "independent", with the token visit).
Remember the running gag from "The Golden Girls" where Sophia, the oldest member of the cast, was often threatened to be sent back to the retirement home of hell "Shady Pines".
Anecdotes based on my experience with mother working as nurse in nursing home, and being American.
The policy, cultural struggle I'm currently having is we won't let the elderly die in peace, with some dignity.
The growing acceptance of hospice and euthanasia, during my life time, has been very encouraging.
But what happens when people are kept alive after they lost their agency?
My immediate family has two people in a nursing home. The sicker of the two is essentially a vegetable and is not permitted to die (feeding tube, other heroic efforts). The some what less sicker is also trying to die, but at least still remembers his own name, can return greetings.
If either of these two men were lucid, they'd be livid to learn they're still here.
There's a guy down the hall who hasn't had any external contact in 11 years. No friends, no family. He's a complete vegetable. It's horrifying.
I've instructed my family that when I'm no longer able to converse, when I need someone to manage my hygiene, to let me die. I do not want to become a long term burden on the living.
I'm so worried about it, I've been researching ways to kill oneself, should the need arise.
To me, it's absolutely not "questionable at best": it's a tremendous step for humanity on a path to a fully enjoyable long life.
On a population-wide point of view, the next step is that the first 60/70 years should be dedicated to building a strong body. Sport and nutrition, done intelligently (no mindless cardio, for example), can do wonders for the last 20 years of one's life.
A strong body can be achieved by virtually anybody with time and dedication, minus specific conditions (laziness is not a specific condition). I'm not talking about being lean and jacked, I'm speaking about strong body, with working joints that have been taken care of during the whole life.
Of course there's medical conditions specific to old age that can't be escaped even with a strong body, mainly brain decay. Science needs to continue its quest here. I've read that there's hints that Alzheimer may be linked somehow (in a complex way) to lack of sleep: I can assure you that you sleep well when you lift every two days, years after years. In the end there's no simply no logical reason to neglect our body.
The bulk of old people in nursing have just completely neglected their body for their entire life, and that's the main reason why they can't enjoy the last years. As a civilization, we should now focus on engaging current generations to prepare their body for the end.
You can assure me, but it won’t be true. Source: lifted at least five days a week for years and was deeply insomniac the whole time
For example he states that for the average 4.7 years of added life expectancy between 1990-2010, 3.8 years added were healthy.
To play devil's advocate, a lot of older people in Asian, Latin, and Middle Eastern societies don't end up in retirement homes.
Yes, they exist, but it's culturally expected for children to take care of their parents in old age (just like the parents took care of the kids when they were young). Sure it doesn't make the quality of your last decades in life much better but I think at least it'd involve less crippling loneliness.
In developped countries the cost (mental, economical, physical) of caring for parents drive away children, and where there was two to three siblings decades ago, in these day and age single childs are plenty.
My Mum is 86 and my father turns 90 Saturday. I live at my Mum's summerhouse currently and most of the people around are around 80 y.o. There is a bias of course (some died and others ain't comming to their summerhouses) but they are active and taking care of themselves.
I have some re-modelling of the summerhouse done by a neighbor who is 80-ty, he has cancer, had a stroke but is very active, optimistic, friendly and God, he is good with his tools and when starts working he can't be stoped.
The healthcare ain't perfect but it is quite good, the pensions are OK and if you managed to stay active and relatively healthy then you can enjoy your time. That's my impression.
Looks like it also needs a [citation needed].
The Concise Oxford Turkish Dictionary, Oxford, 1959, s.v. kırk: "Forty; used especially to denote a large indefinite number
Exist many samples of the use of numbers in the thousands, btw..
In Russian, there's a fairly obvious pattern to numerals like 20, 30, 50, 60, 70, 80, 90. It's not super consistent, but you can easily pick each of those apart and see that it references the corresponding digit, plus some variation of "ten".
Note that I didn't list 40. That's because it's special - it has its own word for it, that is completely unrelated to the word for 4 or any other number. Its etymology is contested, but it's certain that it was already special many centuries back, and used to count things (in groups of 40). And then you have archaic idioms like "forty forties", which basically means "hell of a lot".
Of course, it can well just be convergent evolution - there's only so many round numbers. And then if you pick one as the standard size of the group for counting, and it's large enough, then a square of that number is also a fairly natural choice for "many". But identical choices in other cultures might give the initial push, or reinforce one of the early roughly equal candidates.
I was going to say it stems from Abrahamic tradition, and biblical use as a period of trial, but Wikipedia tells me "The number 40 is used in Jewish, Christian, Islamic, and other Middle Eastern traditions to represent a large, approximate number", with some other older traditions shown.
https://en.wikipedia.org/wiki/40_%28number%29
Presumably Pratchett's inspiration for the Troll number system (many-many-lots) :)
It would appear that a more useful metric is number of centenarians per million. On the 1.1.1960, England & Wales had 11.6 centenarians per million. On the 1.1.1990 this increased to 76.3 centenarians per million.[1]
Another way to look at it is the risk of death for a given age tracked over time.[2] If you were 60 years old in 1900, would you have a higher risk of death compared to 2000?
[1] https://www.demogr.mpg.de/Papers/Books/Monograph2/search.htm [2] http://www.bandolier.org.uk/booth/Risk/dyingage.html
If you're in a metro area, go to your nearest hospital with a labor wing and ask any nurse on staff if they can describe any pattern between characteristics of a woman and how fast she delivers her offspring. The greatest predictor of risk in death of either an infant or a mother in childbirth is duration of labor. The second greatest predictor of labor death risk is age of the mother.
A growing trend in fertility for a long time by now is positive correlation with poverty, illiteracy, and religious susceptibility. There's also a very effective self-interested cultural and economical push towards _certain_ women fully embracing the (in)action of stopping their lineage either actively through choice or even passively through delay by necessity against the ticking time bomb that is menopause to receive better individual outcomes than creating children for sake of retirement insurance when now such old-age risk can now be offloaded to a pooled global society that has a huge reserve of more fertility-friendly cultures. In addition legal incentives and even unintended economic punishments push _certain_ demographics of males towards rationally opting out of procreation in order to stave off undesirable consequences for their wealth and happiness.
Tangentially, it's not something that people like to talk about in public discourse, but there has also been a very prominent trend of decreasing age in the arrival of puberty especially for girls.
All of these factors are are the outcomes of individuals, demographics, and society in general implementing changes to their reproductive strategies and over time these choices reinforce themselves through natural selection. And of course this will reflect on some opaque metrics such as "average life expectancy" if you are not able to sub-categorize the averages.
That is either because we're not actually living longer as a species or there is a hard limit on how long humans can live.
It suggests that life expectancy has gone up sinificantly for all age groups, not just life expectancy at birth.
Notice how I explicity said the word _designing_ and not something like 'calculating' which would misleadingly characterize such a scheme as something that is objectively derivable from verifiable information with valid uncertainty bounds and without the potential for advocating policy with dubious constructed data.
If you've ever thought p-hacking was a riot in academia's social sciences bullshitting, wait until you read through stuff like this with think-tanks coming up with whatever numbers are necessary to justify a policy to secure more funding to shroud misinformation in a thin veil of perceived scientific validity to people who feel comforted if you just put on a white coat. Not only does it go through "careful rexaminations" of methodology with new versions every year tweaking subtle but fundamental things like "we used to assume uniform distributions of births across the entire year on v.5 and as of v.6 now we decided to assume a proprietary non-uniform distribution that flucuates per year (and our policy objectives...) because there were wars that changed reproductive strategies that we conveniently forgot to account for that last year and the error cascades through to every successive year's death risk. Stay tuned for v.7!"
On top of that and pretty much a direct consequence of this so called 'research' being complete bollocks, is that none of this junk is ever peer-reviewed. Couldn't even clear that hurdle.
Sorry to ruin your parade but the statistics accessible via think-tanks and public governments are a complete fabrication. Want to see actual life expectancy tables? You need to buyout a multi-national insurance conglomerate that has survived the test of time with financial crises and political cycles, peeking into actuary tables without the gimmicks of literal data engineering. I highly doubt you, nor anyone here, would ever get close to these secrets. And even then, the usual business model of such corporations that can attain that large of a risk pool and _could_ identify these stats are usually incentivized to profit from regulatory capture rather than the public-face tagline of accurately predicting the likelihood of risk to perfectly balance premiums against claims and extract profit from investing on the float.
[0] https://www.mortality.org/Public/Docs/MethodsProtocol.pdf
The problem is that most others don't have access to the infrastructure and raw data to get accurate numbers themselves (or redo the data collection with better methodology).
Of course, the story is more of a feel-good rationalization of fickle lottery tickets, due to the realism of "the market can be irrational longer than you can remain solvent" even if you're correct and especially due to the incentives involved to keep the insanity going as long as possible, bail out insiders, and conveniently backtrack on contracts due to concerns that actually losing money as a counter-party is not acceptable for the entrenched interests because the boogeyman of contagion would spread as the house of cards comes collapsing down with highly leveraged banks and pension funds unwinding the horrible bets they made that were rationalized by a feeling of untouchability when cozzying up with politicians.
But the details of the story are more interesting in that the methods used, such as realtime satellite based photography to more accurately estimate sales are definitely out of the current realm of accessible infrastructure and data collection methods for mere mortals who know in the back of their mind the stats are a ruse but can't possibly prove it.
So, what's my point on all this? My own anecdata tells me:
1) Eat real food, like those long-lived ancestors. 2) Move / exercise. Most of them were physically active farmers, while I sit here coding away at a desk. 3) Hope you don't have any obvious genetic markers for cancer, heart disease, etc. 4) Be thankful for modern sanitation and immunization! Get your shots, including flu shots!
There's a lot of these scenarios that are well documented, anything from the loosely defined and often poorly understood epigenetics processes, but also the signaling regulation of cell growth and death, resulting changes with hormesis, acclimatization, availability/scarcity of nutrients, hormones, pharmaceuticals, viruses, and even mental state.
(1) is typically the largest factor of all that listed, with experiments showing repeatedly that 'genetic markers' specifying risk for heart disease, cancer, etc all vastly improve with a reduction of excess body fat and elimination of recreational drug usage such as excessive alcohol and cigarettes.
And as for (4), definitely a trump card is not taking a dump in your drinking water supply without reasonable recycling treatment. Many people tend to associate the medical industry as responsible for the supposed improved living conditions of modern developed countries. However, if you look at the repeated succession stages of colonialization throughout the past several hundred years, it's obvious that when people in underdeveloped countries stop shitting in their food and water, illness and resulting death plummet until a few generations later when economically enforced diets and 'sensible medical care' are in full effect leading to a rebound of misery.
Farmers have generally had pretty terrible (imbalanced) diets until the last century or so because one's diet was heavily dependent on the seasons and local climate.
So they invented and clinically tested Intermittent Fasting? Trendsetters! ;-D
I don't disagree with you, but here's my point - they weren't eating Cheesy Poofs and Mac and Cheese, they were eating... greens, legumes, root vegetables, etc. Whatever was local and seasonal or that they could preserve using salting or canning. In this regard, even if there was scarcity, what they were eating was likely better for them than what much of our population calls food today.
Once you got past that, and assuming you didn't get dragged off to war or succumb to some sort of pestilence, life span wasn't so different.
Which makes watching or reading period fiction frustrating when they treat a 40 year old as we might an 80 year old. We live longer, but we sure don't age at half speed.
There was still a significantly lowered life expectancy in adulthood due to disease, hunger, violence, childbearing, accidents.
See for example John Graunt's life table of Tudor period Londoners:
http://www.stat.rice.edu/stat/FACULTY/courses/stat431/Graunt...
Only 25% (!) of Londoners survived until age 27. More than a third of adults who lived to 27 died before age 37. In modern London you can neglect pestilence as almost a rounding error within overall life expectancy, but in some ages of London-past pestilence was the dominant term.
I also did not see any data on sample size, etc.
this seems to say life expectancy was ~50 years if you reached 21. https://books.google.com/books?id=T4DLK7zLxYMC&lpg=PP1&pg=PA...
graunts life table says 33% chance of living to 21. 8.8% of living to 50. Shouldnt it be closer to 16%? if average is 50, means 50% beyond, 50% short. so 50% of 33% would be 16.5%? perhaps Im looking at this wrong
Admittedly, Tudor England was not a very urbanized society, so looking at Londoners alone is also unrepresentative of the whole nation. I think it is at least a bit broader than 52 noble men who managed not to die of accidents or violence.
EDIT: a page later in your source, it also notes "These rates [of death for women] are very high by modern standards... In the 16th and 17th centuries, 11.3% of fertile women died from complications of childbearing."
I cant find it. seems odd to dismiss the data i provided based on sample size when his data is not even avail for scrutiny.
> In the 16th and 17th centuries, 11.3% of fertile women died from complications of childbearing."
great, what was the average age of a woman at childbirth? We're discussing mortality after 21 right?
Here is a scan of Graunt's book "Natural and Political Observations mentioned in a following Index, and made upon the Bills of Mortality." It is old and a bit hard to read. http://echo.mpiwg-berlin.mpg.de/ECHOdocuView?url=/permanent/...
There is also a transcription of it at Wikisource, but it contains frequent OCR/transcription errors:
https://en.wikisource.org/wiki/Natural_and_Political_Observa...
Average age of a woman at marriage was 23.5, and vast majority of births were to married women, so mother's average age at first childbirth was above 24:
https://www.plimoth.org/sites/default/files/media/pdf/edmate...
There appears to be a large collection of the actual bills of mortality scanned and archived here:
As you note there was a lot of death from pestilence. I'm happy for antibiotics preventing minor injuries turning into life threatening infections, and to share house with a few spiders rather than plague carrying fleas and rats.
Gregory Clark details this in his books.
Not just the children, but women too, mothers specifically. Child birth was very risky until only recently. Since they also had a lot more children the risk was really high.
I don't think I ever equated lifespan with life expectancy, I never ever thought you would just randomly die of old age at age 30 or even somehow reach old age at age 30. I merely presumed sickness and war would wipe you out and you would die of something like that than somehow superhumanly jumping into your old age as soon as you hit 30.
Sure, maximum might not be changing much, but the fact that the average has changed so drastically means there has been unfathomably less death and suffering than otherwise would have been. Also, the advances have not been just over the last few decades, but more likely one or two hundred years (i.e. since the industrial revolution).
There are also serious thinkers (e.g. Kurzweil) who think that biotechnology will increase maximum lifespan pretty soon. I found it strange for an article tagged with 'Biology' to not talk about biotechnology potential related to longevity.
To me, it just seems like an (admittedly difficult) engineering problem that we're likely to make a lot of progress on. I'm currently studying biology and it's pretty amazing what humans have discovered in the last ~100 years about how the body works at the atomic level.
As a meta-point, I find it fascinating how nearly completely divergent our bayesian priors are (I think our chances of counteracting all of those forces you mentioned are, on a long enough timeline and assuming we're not destroyed and we have sufficient energy, greater than 90%).
For example, telomere shortening is already being worked on. Look up Bioviva science, they have made first human experiments and results look very promising.
I think people just got used to being fatalist in this regard, because it is psychologically easier than to tackle this problem.
Is this super interesting and important question being given enought attention in the research-community? Or is it super-niche?
I think this is pretty interesting even if you're not religious.
Also, there's some debate about whether that line means the obvious (maximum lifespan of around 120 years), or whether it's actually saying that people have 120 years left until the great flood comes. Most people (and me personally as well) think the former but the latter does make some sense as an interpretation in context. Well, except for the fact that it does mark a point in the Bible where people's reported lives stopped being ridiculously long.
When you fabricate its better if the fabrications concern things either long ago or far away and if the present situation is different from that described you have to explain why if you don't want your audience comparing present reality to prior and seeing through the hoax.
Example if you wanted to posit that insert legendary figure here was 30 feet tall and came from a village where most were 20' and up you can't set the story in the next village last year because someone has probably been there and noticed that people just aren't that tall.
If it was a thousand years prior across an ocean you can claim that people became less mighty as the years went by and lost touch with their gods which plays to people's tendency to filter the past through nostalgia.
If a 30 foot tall giant seems less likely than a 900 year old man then you may need to apply critical thinking skills.
Just because its still socially OK to believe nonsense doesn't mean its true.
Edit: I was wrong about the part below.
As for it being 120 years until the flood, if my memory serves me right, that passage is clearly after the flood (and as a reaction to the 'wickedness' before the flood).
I don't remember anyone living hundreds of years in the Bible after that proclamation (unless they were already alive, like Noah) but you might be right. I see Jacob was apparently 130 or older and that was later on. Is there anyone who lived a really long time that was born after Genesis 6:3? Seems like a good place to spot an obvious "plot hole".
Abraham lived for 175 years, Moses suspiciously lived for exactly 120 years, some medieval commentators claim the genesis verse is a reference to him (although there is no other proof).
Or, if we map 120 <== 969 that's ≃ a factor of 8 shorter life for other notables of that era.
That would, for example, put Methuselah at a much more plausible 80 years.
I think it is a fools errand to try to find rational explanations for implausibilities in mythology. After all, the length of lifespan is kind of the least problematic thing about the account of Adam, if you want to understand it as historical.
It's interesting the a similar way that Eratosthenes calculating the dimensions of the earth was interesting.
Said more simply: If the 120 years bit popped up first in the King James version then yes, that's only 420 or so years old so it makes sense that their expectations for maximum life expectancy might be closer to ours.
But what if we have examples from 1000+ years back?
Why is the oral tradition part so important? Wouldn't transcribed versions of "the Bible" (or at least this fragment) that are millenia+ years old be just as valid?
Probably showing my Biblical ignorance here so apologies in advance if this is a poorly conceived question.
But you are right; next to no-one cares. The thing that is driving anti-amyloid work in this case is inherited disease in which there is excessive amyloid formation at younger ages, and the growing realization that 10% or more of people who die from heart disease in the 60+ age range are doing so because of normal levels of transthyretin amyloid deposition.
If you select people who avoid the ills of modern diet and inactivity, while enjoying modern medicine, you may get a different curve.