He's pretty close to a 4/5/6, an R/W, a J/Z, and maybe a 1 train. That puts him at about 25 minutes from NY Penn, which allows him access to Amtrak or the LIRR.
He's about an hour by public transport from LGA, but that would require a bus. The fastest route to JFK would be 1h11m if he took the A (which isn't all that close) followed by an airtrain. If he chose Newark Airport it'd be something like 25 minutes to NY Penn station + 25 minutes to Newark Penn station and maybe another 10 minutes to Newark Airport via NJ Transit, so about an hour. In other words, from escape to the front door of the airport he's looking at at least an hour of commute, by which point I'd hope someone noticed he's missing.
This all, of course, assumes he takes public transport.