So if I'm reading it right, it looks like it's trying to replicate the DOM interface almost exactly (but in a web worker)! Which means that any UI library should be able to plug into this system and run mostly off the main thread for most of the application's life, bringing JS to parity with a lot of "native" development where you do most of your work on a "main" thread, and only touch the UI thread when you want to do UI things!
It also reads like it might have some kind of virtual-dom implementation to kind of optimize the actual renders needed in the UI thread? (although I'm not very sure about this part).
But this looks incredible from a first glance!