I'm building an app using Bottle as the framework and getting HTTPS to work properly (with a proper certificate) has been a nightmare. I think I fixed it after a full day of research and tinkering yesterday.
This app is super small... maybe 5 users simultaneously, so I don't need the overkill of Django or integrating with something on Apache or Nginx.
REMI looks pretty straightforward and lightweight; even without HTTPS it looks useful... I'll give it a whirl and keep it in my bag of tricks!