It's interesting that you bring up this point because these are all aspects that would have to be taken into consideration before autonomous highway driving is safe for trucks, tire blowouts aside.
Most people think of driving on a highway as the simplest thing there is, but when you have tens of thousands of pounds, sometimes unevenly loaded, sometimes as barrels of liquid that slosh around and change your center of gravity, all that on a stormy, windy, icy day driving in the mountains, it can make for very uncomfortable driving. Is it solvable? I don't see why not, but I think it might be a bit more difficult than it sounds.