As long as Iran agrees to nuclear restrictions in exchange for the financial benefits of sanctions relief (as agreed in the JCPOA), the other members should be safe from a legal standpoint.
Additionally, the EU Blocking Statute [1] came into force, mitigating any sanctions that the US might impose due to companies trading with Iran.
On the other hand, sanctions on a state are usually met with an equivalent response, and the only question is how powerful the other side is. In the case of the EU, the answer is, not powerless.
Look, the US has a lot of cards to play. But randomly bullying banks who didnt do anything wrong, as per your suggestion, is not a particularly effective one, so they won't do that.
It depends. If that would make some voters happy enough to vote Republicans in November, wouldn't it be effective?