VirualBox does not work: https://www.virtualbox.org/ticket/17805

tl;dr: Mojave blocks the VBoxDrv.kext <5.3 kernel extension from loading because "it will panic the machine if allowed to load", and it's up to Oracle to patch on version >=5.3 (current latest is 5.2.18)

Systems that depend on VirtualBox such as Vagrant don't work either.

Some guy has posted a workaround but it involves disabling the SIP, proceed at your own risk: https://silvae86.github.io/sysadmin/mojave/beta/vagrant/virt...