IIRC the NEO only does TOTP over NFC. It sounds like the 5 does U2F over NFC, now?
This raises a more generic question: What's the proper upgrade path for hardware authentication tokens?
This is the reason why I'm still using only a password manager. I agree that a hardware token more security but the lost/stolen/change key problem is really not easy right now.
I hope there will be a new common API to change all enrollment you have done but it seems hard as the key don't even know them.
Maybe in a future version ?