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In a terminal in cooked mode, Ctrl+D sends EOF. Literally any program that reads from stdin and doesn't do something special to avoid it will handle Ctrl+D.

That's the point about why it's worth it to learn: It's universal to all terminal programs, even if the author of the program didn't know about it.

Practically any interactive shell. python or bash for instance. It's everywhere.

Except Powershell. :(

It does on Linux.

Most apps that read from stdin handle EOF correctly.

python and node REPLs both do this.

Any command-line that uses readline[0], which in practice is an absolute ton of things.

This includes nodejs's repl, irb, ed, gdb, tftp, virsh, gpg --card-edit, and others.

It also works for programs that read stdin as if it's a file if you're using a modern readline shell to run them (e.g. cat, tee, etc)

[0]: https://en.wikipedia.org/wiki/GNU_Readline

It has nothing to do with readline, but is a feature of the TTY (i.e. implemented inside the kernel) when in canonical mode. It will work for anything that exits in reaction to read(STDIN_FILENO, ...) returning zero.