In this context being upset at an organization for "tax avoidance and sidestepping labour regulations" seems to me to be about as rational as being upset at water for flowing downhill. What's more, there's nothing inherent to these loopholes that favors American companies, and yet it's almost universally American companies that are being targeted for this regulatory mob justice.
I call sour grapes and attempt to reformulate my original point: American companies, the most vigorous of which have emerged victorious from the survival-of-the-fittest meat grinder of the American business environment, have set their sights on the comparatively sclerotic European continent, and are on a tear. To which the European system responds not by encouraging competition, thereby strengthening its own offerings in the long run, but by backdoor regulatory protectionism.
I'm sure it's satisfying in the short term to siphon off a fine here and a tax there from these companies, but they're just going to keep coming. Either the EU steps up its approach to competition or it drowns in American tech prowess.