Can anyone read the study and actually tell how long or what kind of fasting did it take to gain those results? The article just quotes a scientist about fasting for 24 hours.
From the paper:
Mice strains
C57BL/6J mice were purchased from the Jackson Laboratory. All mice were housed in temperature-controlled rooms with a 12 h light-dark cycle and given free access to water and food. After starvation for 5 h, 8 weeks-old male mice were injected intraperitoneally with PBS, β-HB, or S-β-HB (1.5 g/kg body weight in PBS). In parallel, 8 weeks-old male mice were randomized and fed a regular chow diet or fasted for 72 h. Then, the mice were sacrificed. Tissues were collected for gene expression evaluation in various organs including the aorta, liver, heart, brain, adipose, and kidney (n = 6). All animal protocols were reviewed and approved by the Institutional Animal Care and Use Committee at Georgia State University.
https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)3...
Also note the slightly confusing setup of the study. Some mice were first fasted for a short time (5 hours) then injected with the tested molecules. Then a different batch of mice were fasted for a longer period of time (72 hours). The second batch where tested blindly and at random, the first one where not. To me, that sounds very strange, but I'm not a biologist, so.
Edit: personal experience and some scant scientific evidence seems to point to there being a significant difference between men and women on this one. Men seem to accrue more benefits with longer fasts (diminishing returns though), women seem to get metabolically stressed earlier on. More studies are needed though.
https://www.fightaging.org/archives/2014/06/fasting-can-be-u...
This the actual source:
"Here we report that β-HB promotes vascular cell quiescence, which significantly inhibits both stress-induced premature senescence and replicative senescence through p53-independent mechanisms.
Further, we identify heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) as a direct binding target of β-HB. β-HB binding to hnRNP A1 markedly enhances hnRNP A1 binding with Octamer-binding transcriptional factor (Oct) 4 mRNA, which stabilizes Oct4 mRNA and Oct4 expression. Oct4 increases Lamin B1, a key factor against DNA damage-induced senescence.
Finally, fasting and intraperitoneal injection of β-HB upregulate Oct4 and Lamin B1 in both vascular smooth muscle and endothelial cells in mice in vivo. We conclude that β-HB exerts anti-aging effects in vascular cells by upregulating an hnRNP A1-induced Oct4-mediated Lamin B1 pathway."
https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)3...