We know that Carbon is essential in creating these self replicating entities. Its abundance is also known in the universe. So, it is not so unrealistic to presume that aliens won't be something that we can see on earth. I am curious of the differences of the forms of life that can originate though.
Imagine if we rerun 2 billion years of evolution again with a different initial conditions. Surely, we'd have different forms. Contrarily, eyes have evolved independently in many organisms over a dozen times. So, there is some commonality there. Just like the eye, there are many similar biological processes that evolve independently (arteries/veins, neuron, heart for circulation/extraction, ceramic structural components/bones, etc.)
I used to think about the same question that you are also wondering but the deeper you go down this rabbit hole, you are realize the importance of why things in living beings are the way they are. They're solutions (however imperfect) to an evolutionary problem.