Roselló-Díez A., Madisen L., Bastide S., Zeng H., Joyner A.L. "Cell-nonautonomous local and systemic responses to cell arrest enable long-bone catch-up growth in developing mice." PLoS Biol. 2018 Jun 26;16(6):e2005086. doi:10.1371/journal.pbio.2005086
https://journals.plos.org/plosbiology/article?id=10.1371/jou...
* tell what is the messaging system (I understand it is some kind of IGF peptides),
* what are the semantics of the messaging system (how can it report about the length of a limb? how are identified senders and receivers?)
* what is the controlling system (which compares the two limb lengths and corrects the lengths by sending other messages?)
Many thanks!
But yes: the data is signalled in the form of pools of individual molecules. The messaging system uses tags to target molecules (in some cases) or just controlled spatial relase to target the messages.
The controlling system is a complex set of genetically regulated proteins and other components.
See morte here: https://en.wikipedia.org/wiki/Cellular_communication_(biolog...
None of this is fully understood but it has been extremely successful in explaining a lot of more complex developmental phenotypes.