Even if there are some locations that accept innovative experimentation with drones (e.g. Switzerland or Japan), the majority of countries (e.g. the USA with part 107) are quite restrictive. Because of severe restriction on autonomy, all large-scale applications are not legal.
Not many people are investing time and money into building new drone applications, as it's uncertain it will be legal in the near future. Without serious $ behind it, drone regulations will probably stay restrictive. If you are thinking about Amazon - I heard from multiple people that last-mile delivery is actually more feasible with ground robots.