I don't see much Apple is likely to do to help. They could bless a package manager as official, include it in OS X, and pay for build-boxen and for people to work on it; but you'd still need a lot of community involvement, and that's not Apple's cup o' tea.
Apple could also just make a few things easier about building nix packages: Currently the OS X linker will automagically look for libraries in /usr/lib and /usr/local/lib by default, this should become easier to turn off so that packages don't end up with hidden dependencies on stuff the user threw in /usr/local. * A lot of libraries that are extremely common on other nix aren't included in OS X, eg: readline, iconv, gettext. But many of these are GPL3, so don't count on Apple being helpful. Universal, backwards-compatible binaries are currently a PITA to build from the command-line. You need to specify the SDK, DEPLOYMENT_TARGET, and compiler separately; and then if you ended up using different SDKs for different architectures, you need to use lipo to combine the results. Some way to specify all this stuff at once, and use sensible defaults would be great: 'gcc --sdk=ppc/gcc-4.0/10.4 --sdk=x86_64/clang/10.6 ...'