Facetime compatible iChat would be nice.

More gestures for the magic trackpad.

Improved Time machine (I want all to see all previous versions of a particular file, not row through a timeline of a directory.).

Improved automation (Automator is still not natural enough, lots of clicky dragging.).

Frameworks start to encourage 3rd party applications to continuously auto-save like iOS apps.

Don't want to see but will probably see: Lots of "social" junk, like Ping for iWork or something that nobody will actually use.