Are you saying that as a company grows larger its business model becomes MORE precarious such that they can no longer afford experimentation or optimization of any kind?
I work for a F500. The top brass of the company sincerely want us to move into new areas. So they just buy companies that are already innovating.
People recognize the problem of big companies trying to innovate. One solution is to create isolated innovation teams that function more like smaller companies. I work in one of those teams.