But lacked fine grained control, at least the last time I used it. With uMatrix I can tell the browser to disable something (cookies/script/frames/media etc.) here but keep it enabled else/everywhere and the other way around. It gives the finest possible control but of course requires some time to whitelist the good stuff on new pages. A minor annoyance compared to the control it offers.

Yeah, noscript is pretty powerful.

The biggest difference between the two, in my experience, is UX. uMatrix is the best UX for a content blocker I've ever seen - very intuitive and simple.