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Comment by meowface | Hacker News Reader

To my understanding, MAOIs only pose a hypertension risk in combination with stimulants like tyramine, caffeine, amphetamine and derivatives, etc. DMT isn't a stimulant.

Also, hypertension risks are generally a problem for MAOI prescriptions: people who take MAOIs every day. With DMT, a MAOI is only consumed once, with the DMT. DMT is rarely taken on a regular and frequent basis, so it's unlikely someone would be consuming a very risky quantity of MAOIs over the long term.

MAOIs may increase DMT risk in other ways, but I don't believe hypertensive crisis is an issue for that specific combination.

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> To my understanding, MAOIs only pose a hypertension risk in combination with stimulants like tyramine, caffeine, amphetamine and derivatives, etc

They pose a risk with alcohol and lots of different foodstuffs too - https://www.mayoclinic.org/diseases-conditions/depression/ex...

> MAOIs may increase DMT risk in other ways, but I don't believe hypertensive crisis is an issue for that specific combination.

Not with DMT itself, but if taking an MAOI at all you need to take a lot of precautions (fasting, avoiding certain foods and drink etc) to avoid the possibility.

It's manageable, clearly, but just blanket saying not only that it's fairly safe, but that it's the only fairly safe drug disregards the specific risks associated with MAOI use over and above those presented by (for instance) LSD or MDMA.

All those precautions is when you ingest it. Research.

I actually had a bunch of caveats like those in my original comment, but edited them out because I felt like they were unnecessary. Yes, MAOIs definitely shouldn't be taken in combination with foods or beverages or substances which are contraindicated for it, but that's mostly an issue for "non-selective" MAOIs, and is unlikely to affect someone who only takes a single MAOI dose once per year.

I just meant DMT isn't known to pose a particular risk when combined with a MAOI, unlike taking a MAOI with amphetamine or something. Obviously people should research what they should and shouldn't take with them.

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