The only major disadvantage of OSM-derived applications is the lack of real-time traffic information. Google Maps harvests data from phones inside cars and some car navigation systems. They also buy it from third parties.
http://opentraffic.io/ is trying to do some data harvesting, but it's still not very good. Another option would be to build an aggregator. Lots of governments publish real-time traffic data, so it should be a matter of integrating that into an OSM layer.
Lastly, there's this old technology called Traffic Message Channel which uses RDS (digital data on FM radio) to broadcast traffic warnings. It's quite popular in Western Europe. There's already a F-Droid application that is trying to provide an interface for that: https://f-droid.org/en/packages/com.vonglasow.michael.qz/
I cannot stress how important live traffic information is. Without live traffic, navigating on densely populated areas is a nightmare. It's the only part of my mobile workflow I can't do using F-Droid applications. I'm currently forced to use a web version of Google Maps.