Just checked it out, 100% wouldn't be useful for me. One of the issues with my inability to read is that my mind continually gets distracted by everything and anything around the letters, even in the grey scale mode it induced a lot of frustration. Changes in colour/tone are extra distracting, and it's hard to describe the feeling when you're continually checking in the back of your mind if these extra things are needed/matter. Another odd example of this is that every time the white bubble around the date box on the top of slack breaks a new line, my eye gets pulled there and I have to go back to the bottom to find the text again. Absolutely exhausting.
Damn this idea is really cool and works for me. I wish I knew this site existed much earlier
Fun fact: BeeLine Reader was launched via a Show HN!