Even with webpack or some other complex bundle, someone without any formation can really quickly set it up and get to code without worrying much about the internals of webpack etc.
<script src="https://unpkg.com/babel-standalone@6/babel.min.js"></script>
<script type="text/jsx">
/** @jsx m */
// your can use jsx here
</script>
But if you're new to a framework and just want to experiment then being able to create an html file with a couple of script tags and writing code removes many barriers to entry.
React, Vue and many others already offer this, I thought it was worth mentioning that Mithril does this too.
npx create-react-app MyApp
There is nothing to install, and you have a complete playground to experiment.
That link preloads mithril in a web playground and you're ready to go in a couple of seconds. You can even download and continue development locally should the need arise - without the gorilla and the jungle hiding behind it.
Also taking the time to set up your project with what's just needed will allow to dodge a lot of bullets of breaking or useless dependencies, malicious dependency update tc.