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Comment by wp381640 | Hacker News Reader

I went through a similar experience. About 10 years ago I was in a bit of a funk and depressed, anxious etc. and further I think I was in denial about the problem. I was almost completely unproductive for about 6 months.

Went out one weekend and had a mid-range dose of MDMA and with the afterglow in the days later I felt like a new person, complete with a spring in my step.

It felt like I had been hoarding a lot of useless stuff in my mind and never being comfortable in my head, while MDMA was the clear-out I needed.

I wouldn't advocate for each depressed or anxious person to try it as a cure-all, but I definitely advocate for more research (and have donated to the cause) and greatly reducing the stigma around the drug

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"It felt like I had been hoarding a lot of useless stuff in my mind and never being comfortable in my head, while MDMA was the clear-out I needed."

I know exactly what you mean. You hit the nail on your head. It's like "Oh, why do I spend so much time worrying about little things". It just grabs the shit and dumps it out. It's the greatest perspective on life and love and the best way to reorder your priorities.

I'm wondering what you consider a mid-range dose.

1mg / kg (or just a little more)

I only later learned more about dosages and found that the downsides are at higher (1.5mg/kg+) doses and with long re-dosing

I don't mean to be rude, but not only is 1mg not a 'mid-range' dose, but it's not even enough to get effects from the drug. 100mg is ~average for a small/beginner dose (usually cost $5-10), could that be what your thinking?

Source: My own and my friends' experiences.

Edit: my apologies, I didn't see the /kg part of your equation. After doing the math, yes that seems like a reasonable beginner/small dose.

1mg per KG of bodyweight

Given the high individual variance, dosing psychedelic substances by bodyweight isn't usually considered very effective at estimating the final effect.

Always start with a low/threshold dose first and go from there (this might be less practical for MDMA, where you want to limit repeated exposure).

Do you mean 100mg / kg, like the parent was talking about? 100mg total would be roughly 1mg / kg for my body weight.

I would barely feel anything at that dose and it would be incredibly short-spanned; more like cocaine. It's literally 75% of the dose for ~20% of the effects.

Besides, if you would have read the article - they are mentioning dosages of 125mg.

I would also be confident enough to say that MDMA is not as linear in dosages against body weight and _almost_surely_ it depends way more on your digestive than your body mass.

PS: to be clear, I did this with people who were multiples of my own weight (68kg) and incredibly petite ladies who were smaller than me. Dosage has little correlation with the effects they would get.

I would suggest the quality of the drug matters far more than the digestive system. And that the difference between first-time experience and hundredth-time (which I don't think is a particularly healthy number of times to hit) is quite large.

Well, I would not suggest that since in most of the settings I had participated, people would be taking the powder from the same source.

So I’ve got a feeling that your point comes from reading some info on the internet, rather than your own experience.

I meant that you're in no position to cast judgement on the guys dosage on his first use, especially since you have no idea whether he got very high purity stuff from the dark web or a crushed-up pill, or any idea at all really: and I bet that if you're taking such high doses, half of it is likely speed.

I can't believe I'm saying this on HN, looks like it's finally just another subreddit: I have plenty experience, sure.

Really? If anything I would say that the rule of thumb (anecdotal) is 1 mg / lb.

Smaller girls I knew would be fine with 100mg doses and big dudes would need about 200mg or so. Most people would do 125mg - 150mg.

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