Going a bit controversial here but will self-driving cars be disrupted before they even take off. The big factor that I feel will impact how autonomous travel will evolve in the future is drone taxies/cars. Providing there is a change in the regulation to support self-driving flying cars/drones, the big advantage is that there would be no existing rules created for human driving (road signs, traffic lights...) to adhere to. A centralized system could calculate the best route to fly someone from A to B without the complexities that self-driving cars have to solve. And flying would clearly be much faster as well. Dubai, for example, is already testing, what comes after will be interesting.