highlight:
A549 CDDP-resistant cancer cells showed reduced tumor growth and longer survival in response to periodic fasting cycles (24 hours of water only twice a week). In contrast, CDDP-sensitive tumors were not affected by these 24-hour fasting cycles. Because previous results indicated that 2–3 consecutive days of fasting were effective against a wide range of cancers, particularly in combination with chemotherapy (Lee et al, 2012; Bianchi et al, 2015), it would be important to test these longer fasting periods on A549 and other CDDP-resistant cancer