I use twilio to send myself SMS notifications programmatically, such as when a multi-hour compilation completes, when DNS for a particular domain has propagated, or when my crawler detects that a new job had been posted to a local company's website. These notifications make my life easier, but my privacy isn't protected with SMS.
I would much prefer to have these messages delivered over signal than over SMS. I hope twilio will also consider signal messenger integration in the future.