I don't think so: TypeScript/JavaScript-Types are too coarse-grained for optimizations: For example number is a double in JS. For generating good machine code you really need to know whether the number is int or double. The same for string: Depending on the JS engine there are actually a lot of different string types.

Even if we consider that good enough or somehow solved, understanding type annotations only helps you reaching peak performance faster. It doesn't really make peak performance faster.

Also there are the PyPy and Dart devs that in theory could use type annotations, but both don't. For PyPy they even have an entry in the FAQ: http://doc.pypy.org/en/latest/faq.html#would-type-annotation...