well flex = a flash widget and javascript is just output as part of the template/html.

Are you talking javascript <-> flex, flex <-> HttpService in django and/or django with ajax?

Frankly I find ajax/flex/flash with django to be easier than asp.net webforms since you just setup a route (REST-like if you want) and then "post" to it and return some data and use it in javascript.

In ASP.NET it's not all that hard, but I just have to remove any master pages and remember to clear out the .aspx page contents if I'm not returning HTML.

I really don't see how it's any different than any other ajax + some server technology, so if you're used to ajax <-> php, then ajax <-> django is no problem.