XCode also had issues working with large repos. Perhaps they were talking about that?
They're whole schtick was "we're Facebook and we have unique scaling needs that no one else does," which makes absolutely no sense from the perspective of one user's content being rendered on their phone.
Plus the presenter was pretty smug, like all of this was good, when he wasn't convincing anyone that it was even necessary.
Found the slides: https://www.columbia.edu/~ng2573/zuggybuggy_is_2scale4ios.pd...
Facebook patched Android Dalvik to increase the "max methods per app" limit.
Don't know if there's a similar iOs story.