Really? What's the best Linux distro/toolset to use in order to get anything to show up in a usable way in HDPI? I don't think you can buy new monitors anymore that are at low enough a resolution to support modern Linux.
I literally run FC28 on 4K monitors and at 1.25 scale on my 1440p T480 and I don't even think about it.
Wayland pretty much just works and has for at least a year.
All the ultrawide 21:9 screens are "LoDPI" as well, and at 1440p or 1600p they're great for coding.