The key role that medication plays is to shake you out of a vicious cycle; it gives you a window, a break from the deepening groove your mind has gotten itself into so that you have the capacity to do other things that will have a more lasting effect. It doesn't solve the problem all by itself, yet many people expect it to.
(Speaking as someone who's dealt with depression and who has many friends with varying combinations of depression and anxiety, who have taken varying strategies for dealing with them.)
The negatives have affected many people, and who knows just how many and even how bad the side effects are for people.
Being driven over the edge, to suicide, is horrifying effect of some of the drugs. Others have gone on killing sprees because the drugs drove them insane, while taking them or from the withdrawal effects.