Too much scrolling (which I thought was established as bad in Web Design 101 though I'd love to hear otherwise as 37signals have ignored this for a while), and the lower sections manage to feel crowded despite having white space in abundance (possibly due to using fonts as large as 18.5 pts for paragraphs of text), the font sizes seem to be almost at random section by section.
It's nice that it doesn't look like every other website but beyond slight originality it doesn't do it for me.