Does it hinder Linux gamers who are using Wine? A lot of such anti-cheats can't figure out when Wine is used and ban Linux users. Some also ban custom D3D implementations like DXVK even if they are really correctly implementing the API.
Yes - it hit the news that LoL will no longer work on Wine or virtual machines because of these anti-cheat measures.
OK, then their anti-cheat implementation is bad.
Can't speak for Wine users, but VMs are working now. The workaround was found within days of the patch (they were just checking for the CPU feature "hypervisor"), and they actually ended up rolling back that check due to the community response.
They rolled that back rather quickly.
Blizzard had a huge banwave for users running SC2 WoL under Wine.