My bet's on some unforeseen bottleneck that affects search and static pages. Almost everything within Amazon is crazy scaleable, but there are some bits where you scale them up and their behaviour changes radically. For instance, a service's cache misses might skyrocket as customers get distributed over a wider set of servers, causing service response times to increase just a little bit on average, tipping a dependent service over into more frequent timeouts, causing its downstream service to blow a timeout-percentage 'software fuse' and stop using that service... etc etc.
Given that each of those services (and many more possibly-related ones) will have an on-call engineer paged into a conference call when the manure hit the rotating ventilation apparatus, there are going to be a lot of unhappy people cancelling their weekend plans right now. I definitely don't miss that aspect of the job!