Separate metering for end users? Targeted agreements with large hosts? Same metering for all, screw those who are frugal with packets.
Expand that hypothetical a bit more, so that we can determine if the situation you're asking about is one that ever happens in the real world. Are you asking about traffic imbalances at peering points? If so, the agreements in those cases are between ISPs and do not include end users like Netflix as a party to the negotiations or payments. The primary purpose of an ISP is to ensure that their subscribers don't have to worry about whose lines their packets might travel on to get to their destination.
Beyond that, there is some "discrimination" I would be just fine with. For example why should the end consumer pay the cost of YouTube ad data?
The fear is of course discrimination on political or ideological grounds, not just economic. but it would be fairly obvious and nearly impossible technically for an isp to pull that off. And a net neutrality regulation or even ownership at the state or local level would be perfect. You only need net neutrality at the end points where there is no competition, not in the network at large
That's not what the cost structure looks like for ISPs, so you would need a pretty good justification for making the price structure look like that. It doesn't necessarily cost the ISP more to have packets travel across more hops within their network; it's more likely to reduce the ISP's expenses by reducing the amount of traffic they have to buy transit for. Where a packet is within the network really only matters and becomes worth tracking when a link gets congested.
Metering would be by bandwidth used, so those who are frugal with packets would inherently pay less.
Your grasp of the concepts seems confused.