The real fun starts when you need to do advanced debugging, the toolkit doesn't cover your use case properly or you hit performance problems you can't solve in the non-native language :)
I'm not sure why it would, I'm not doing anything outside of UI logic and interfacing with web services, so it's almost like all other React.js web development for me. Perhaps that's the sweet spot.
Whoa! Whoa! Are you suggesting that the end experience with a programming framework might depend on the details of your specific project and should not be inferred from general blog posts? That's insane! /s