Microsoft, IBM, Oracle, etc. companies that make money from legitimate sources would be barely effected at all (and many tech companies who have huge patent portfolios have spoken in favor of ending software patents or making them less broad). And, startups could breathe a sigh of relief and stop worrying about being the subject of extortion the day they turn a big enough profit to be a target of patent trolls.
Besides, this is about how the USPTO grants software patents. It's not about revoking them or abolishing existing patents, though lawsuits to break some of the more pernicious ones probably would follow.
And what does "aggressively" mean? Making a patent unenforceable will have the same effect as invalidating it.
I'd need to see some evidence of this assertion. When I was spending a lot more time researching tech stocks than I do now (now I spend 0 time researching tech stocks), I never saw a patent portfolio as a significant portion of the value of the companies I was investing in. Revenue and growth is king in tech company stocks. Book value is pretty much considered a big goose egg in software companies because they tend to have so little of it compared to old blue chips that have factories, brick and mortar stores, or infrastructure that has real world value. I'd be absolutely stunned if marking down their entire patent portfolio had more than a 1% impact on their market value, because I suspect even less than 1% of their revenue comes from patents...and revenue and growth is how people value MSFT.
So they'll be making the same money, with less legal risk. If the market is silly enough to crash in response to that, I'll hustle out to buy as many shares in the crashed companies as I can.
The USPTO should consider economic ramifications of a decision to stop issuing software patents, or to invalidate patents. I'm not saying they should not go ahead and do it, but it would be irresponsible not to consider any potential negative effects.