I can't believe that's possible. I really want to know where that number came from.
Maybe you could reduce the weight of just the frame of the fuselage by 50%, but I bet you'd save at most 2-3% of the total takeoff weight, once you include fuel, wings, tail, engines, gear, cabin, baggage, people, cockpit, etc.
Edited: I looked into this more deeply and found the following: https://aerospace-europe.eu/media/books/CEAS2015_211.pdf
It claims a total possible weight reduction on an A320 from 2155kg to 1560kg, or 600kg off the fuselage (plus an additional 150kg elsewhere for a total savings of 750kg). An A320 weighs 42,000kg empty and 78,000kg at takeoff. 2155kg is probably the weight of the fuselage frame sections containing the windows - makes sense that you could save 50% off that piece.
That's a reduction of 1% or so off the takeoff weight.
Also, note that cargo planes are already windowless. I couldn't find a good example of a plane that has both freight and passenger versions that are otherwise identical.