There will be another opportunity when existing fleets are used up and fuel costs continue to increase. Converting stripped A380s into freight might be a good option.
Couriers use spoke and hub model that A380 is well suited for.
The current A380s are not a good fit for freight (lack of nose loading and crappy density), and ironically the freight logistics actually make the A380 harder to use. This is because the most efficient way to do overnight and freight traffic between Europe, Asia and America is to centralize traffic in places like anchorage with a fleet of smaller planes that go to smaller cities. (IE, traffic can go directly from Denver to Shenzhen via a 767 to Anchorage, and another 767 from Anchorage to Shenzhen). You can't put a A380 on each leg of that.