I don't share your pessimism about the list of downsides, and am honestly surprised, as while normally I chuckle at the "HN is always negative" sentiment, this post being the top reply is a real head scratcher, as someone who is both 1. on a >75% remote team, and 2. who has been advocating/watching HN advocate for remote for quite some time.
I'd say "missing real human contacts" is summarized well under a combination of harder rampup/scares some potential employees; as the lack of "Real contacts" seems more of a personal/subjective or team-process-and-tooling-rooted feeling than anything I've observed to be inherent and unsolvable; it's trivial for me to get a face to face with anyone on my multi-national team. Now, to try and read this charitably, if you meant something like "increased difficulty networking" I'd actually agree, but again, if you're at a place in your career where you accept that, it's significantly less of a downside.
Mostly, that's the gist of a lot of the things people list as hard negatives to my ears, including your second point of harder life/work separation. I don't mean to be dismissive, but "that seems like a personal problem." (Edit: see my clarification in child post re: this wording, I came off more accusatory than I'd have liked, but didn't want to rewrite history) With the broad slew of coworking spaces, home offices, coffee shops, and other ways to partition one's time and mental spaces, I don't accept that that's something that can't be solved in the same proactive fashion as a professional would approach any assorted social frictions one might run into in _any_ office environment.
If you read any frustration in this, it comes from a place of, "a lot of the complaints I read are solvable problems or isomorphisms of in-office problems", and a hope that we'd be self-interested enough as a field to be more proactive in seeking solutions, given the benefits that can come from a more distributed workforce. I want to encourage and productively improve sites that try to support this, and part of that is avoiding a re-encroachment of remote work stigma/fear in many people's eyes.
Edit: yes, I'm going to break the HN rules, but christ people, at least _respond_ before blindly downvoting. This was not a glib response, and this topic (remote work) is something we should be able to discuss in good faith without accruing negative score before I even finish grammar-checking my own writing.