It does support hot-code reloading, the preeminent build tool for Clojurescript:
https://github.com/bhauman/lein-figwheel
has that out of the box. As for an actor model implementation, there is pulsar:
http://docs.paralleluniverse.co/pulsar/
Which has erlang-like actors, though some might suggest that core.async and its channel implementation provides everything you might need an actor for, YMMV.