Gotcha. Yes, while there are implementation techniques that can help (e.g. arena allocation, prefix compression, adaptive node sizes), the data structure is fundamentally a tree, and so one can expect a higher number of random memory accesses (when compared with suitably optimized hash tables, like those discussed in the article).

In some scenarios, radix trees can overcome that with better space efficiency (i.e. implicit key storage), but I think it's fair to say that there are many scenarios (if not most!) where hash tables outperform radix trees.

Of course, that all hinges on how you measure performance. As Salvatore pointed out, if you're looking to minimize variance, hash tables might not be suitable due to their growth characteristics. Radix trees also give you efficient sorting and range scans out of the box, and are a viable immutable persistent data structure as well. If none of those are meaningful to your use cases, then hash tables could certainly be a better fit.