This assertion may sit outside conventional medical science and mainstream accepted wisdom, but it aligns with my own experience.
After trying unsuccessfully for years to overcome depression/anxiety, chronic fatigue and other mysterious illnesses (asthma, skin problems, headaches, back tension/pain) using conventional/material remedies (antidepressants, exercise, diets), I added emotion-based treatments to my regimen about 6 years ago, and have had much greater success.
In particular, I've undertaken practices that identify negative beliefs, traumas and sabotaging behavioural patterns that are held in the subconscious, then allow these issues to be understood and resolved. Self-criticism has been big part of what I've been able to work through.
It's been no quick fix (it seems I've had a lot of baggage to work through), but bit by bit, as my emotional health has improved, my physiological health has steadily improved, as have all the outer-world indicators like relationships, productivity and career.
I'm now comfortable suggesting that this approach is overlooked by mainstream medicine to the great detriment of many people suffering chronic illness, and given the link with inflammation that has been suggested in this article and elsewhere, and that I seem to have experienced myself, far more progress could be made in addressing inflammatory and autoimmune illnesses if this approach were to be taken seriously.