I am regularly shocked by how little imagination commentators in the popular science press seem to have on this subject. Even highly-respected scientists frequently refer to "requirements" for extra-terrestrial life such as carbon-based chemistry, the requirement for water, a mechanism of natural selection, etc, etc. (Actually I consider the last one, posited by Dawkins, to be probably the closest to the truth.)
I guess it's simply the anthropic principle at work, but even the nature we see on our own planet far surpasses our imagination often (especially at the microbial level), so why should we be placing any constraints on the rest of the universe?