It means that a freemason have to hold contradictory positions as true. One might be an atheist by one cannot reject the so-called supreme being, one might belong to an Abrahamic religion but one cannot reject the Hindu pantheon. And within the Abrahamic religions it's more contentious than anything.
It's an expression of the Orwellian "2 + 2 = 5", and it's a very dangerous anti-realist totalitarian ideology, and it should be rejected whether you're a theist or an atheist.
In ceremony/ritual we refer generally to "The Grand Architect of the Universe", instead of any specific diety.
BTW, Freemasonry is NOT intended to be a religion nor a replacement for one, and we don't want to be. We just use symbols and allegory that relate to the story of the building of King Solomon's Temple.