1) WPF - I am trying to use this in my work life. It scares me when I hear your ex-product manager twittering that it's dead. I now feel like I should've done my app's front-end in qt or swing.
2) Will microsoft create in-built, tested, virtual desktop support already? More people use laptops that need it even more. I use virtuawin, but things just don't work elegantly. Mac OS X supports virtual desktops natively, and it works without a hitch.
3) The one thing I actually do like that comes out of microsoft are your office products. I think as people actually go paperless now, it's a good time to double down on investing in OneNote as a platform used across tablets, phones, and PC's. Also allow for one to sync it to say, their windows home server, and let one define tags to be whatever they want -- and you may have something that will make me committed to the platform.
4) It's 2010 and I still use cygwin or a virtual instance of linux just to have a console with the commands I want. Windows PowerShell came wayy too late for me to want to bother spending time learning it. Mac users don't have this problem.
5) Start defining some rules for say "windows experience" PC's. This can be an upper-tier for laptop makers to try and not be cheap. This comes from my frustration last april when trying to buy a new laptop. Go into any b&m store, look at the windows machines - feeling like cheap plastic, glossy screens, and meh build quality - then walk over to apple's corner. It's a night and day difference. There's high-quality PC laptops made (ex: lenovo T series, HP envy), but they're hard to find in stores, and are typically only found online. Microsoft needs to define some rules on what a great PC has, similar to what they're trying to do with windows phone 7.