I've always found Qt and Python (PyQt and PySide) to be a weird match. So many times did I end up with cryptic segfaults in the python VM due to some python object being collected "too early", creating a dangling pointer in the C++ world. This can happen if you forget to set the parent object, for instance.

I know that those are things you have to worry about when you write C++, but when in the python world, you kind of expect everything to be refcounted for you. If I ever have to write a GUI app in python again, I'll probably chose another framework.